The thought of death should usher us towards whatever happens to matter most to us; it should lend us the courage to pursue the way of life we value in our hearts.
You have to be willing to fail, to be wrong, to keep pushing forward even when everyone tells you you're crazy.
The universe we observe has precisely the properties we should expect if there is, at bottom, no design, no purpose, no evil, no good, nothing but blind, pitiless indifference.