Change is hardest in the beginning, messiest in the middle, and best at the end.

The great tragedy of Science—the slaying of a beautiful hypothesis by an ugly fact.  

The past is never dead. It's not even past.

If you want something you've never had, you must be willing to do something you've never done.

"The day I stop improving is the day I should stop racing."

建筑不仅仅是关于建筑物，而是关于让生活更美好

最让我兴奋的是基础科学改变医学的潜力。

Every building is a kind of confession.