I like crossing the imaginary boundaries people set up between different fields—it's very refreshing.

I think it's important to take risks and to challenge yourself. That's how you grow as an artist and as a person.

Your smarts will come in handy because you will travel in a land of marvels. We humans -- plodding as we are -- will astonish ourselves. We'll invent ways to generate clean energy and a lot of it. Atom by atom， we'll assemble tiny machines that will enter cell walls and make repairs. This month comes the extraordinary but also inevitable news that we've synthesized life. In the coming years， we'll not only synthesize it， but we'll engineer it to specifications. I believe you'll even see us understand the human brain. Jules Verne， Mark Twain， Galileo， Newton -- all the curious from the ages would have wanted to be alive most of all right now. As a civilization， we will have so many gifts， just as you as individuals have so many individual gifts as you sit before me.

If you do what you’ve always done, you’ll get what you’ve always gotten.

"Every role I take is a piece of my soul that I leave behind."

Every woman has a story, and every story deserves to be told.

We're in the business of entertainment, but we're also in the business of enlightenment.